If you’ve been scanning supplement labels lately, you might’ve seen the word methylated and wondered what the hype is all about. The truth? It’s not hype. It’s your biology.
Feeling tired even when you’re doing everything “right”?
That could be your body struggling to process standard forms of nutrients — especially B vitamins. Millions of people have a common gene variation (like MTHFR) that makes it hard to convert synthetic vitamins into their active, usable form. That’s where methylated nutrients come in.
What makes a methylated multivitamin different?
Methylated multivitamins use the bioactive forms of nutrients — the ones your body can actually absorb and use right away. No heavy converting, no lost potential.
Some of the key players:
-
Methylcobalamin (active B12)
-
5-MTHF (L-methylfolate) (active folate)
-
Pyridoxal-5-Phosphate (P5P) (active B6)
In contrast, standard multis often use:
-
Folic acid (less bioavailable for many)
-
Cyanocobalamin (a cheaper B12 that requires conversion)
Why this matters for your health:
If your body struggles to methylate, you may feel:
-
Fatigued or foggy even with good sleep
-
Sluggish with detox or stress
-
Prone to mood dips or anxiety
Taking a methylated multivitamin skips the conversion step — so your body gets what it needs without the extra effort.
Who benefits from a methylated multi?
-
People with MTHFR or related gene variants
-
Anyone with energy, mood, or hormone imbalances
-
Those looking for optimal nutrient absorption
-
Anyone who wants to support detox, cognition, and cellular repair more effectively
Disclaimer: This article is for informational purposes only and does not substitute for professional medical advice. Always consult your doctor before starting any new supplement. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.